中国科学院数学与系统科学研究院
数学研究所
数学科学全国重点实验室
动力系统研讨班
Speaker: 李勇（长江大学）
Inviter: 朱思尧
Language: 中文
Title: Global dynamic and clinical data analysis of an age-structured virus-humoral immunity model with cell-to-cell transmission and general incidence rate
Time & Venue: 2026年8月29日（星期六）10:50-11:30 南楼N913
Abstract: HIV latent reservoirs represent one of the major obstacles to an HIV cure, providing a “safe haven” for the virus to evade both antiretroviral drugs and host immune surveillance. In this talk, we present several dynamic models characterizing the synergistic interactions between HIV latent reservoirs and host cellular and humoral immunity, including stochastic delay models and age-structured models. We analyze the well-posedness, global persistence, and stability of the proposed models. By calibrating the models with clinical data, we investigate optimal antiretroviral therapy (ART) regimens and elucidate the underlying immunological mechanisms.
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